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Nanoknife in cancer treatment at Fuda Cancer Hospital, Guangzhou, China

Nanoknife can cause accurate apoptosis of tumor cells, which made possible complete ablation of the tumor. It does not damage important tissues in the ablation area, such as blood vessels, bile ducts and nerves; therefore, the complications caused by treatment with a nano-knife are much less than those caused by any other treatment.

At Fuda Cancer Hospital in China, a nanoknife is used to treat tumors in solid organs such as the pancreas, liver, lungs, kidneys and prostate, and is especially suitable for tumors adjacent to the pancreas, liver, gall bladder, bile duct and ureters.

The benefits of nanoknife therapy

1) Short ablation time

For solid tumors 3 cm in diameter, nanoknife therapy takes only 90x100 million seconds of ultrashort pulses. One treatment cycle takes less than one minute, and it takes less than 5 minutes to remove 3-4 overlapping treatment areas.

2) Preservation of important tissues

A nanoknife can protect important tissue structures in areas of ablation. Important liver structures such as the hepatic artery, hepatic vein, portal vein, and intrahepatic bile ducts may be well protected during treatment.

A nano-knife is the best choice for a patient with breast cancer who wants to save their breasts.

3) The lack of the effect of the thermal island

The nanoknife system uses electrical impulses to destroy the cell membrane. The procedure will not generate energy, and will not be affected by external temperature. During traditional thermal ablation or cryoablation, energy will be taken from the bloodstream. If there are large vessels in the ablation zones, this leads to incomplete ablation in the treated area, which does not occur during treatment with a nano-knife.

4) The ablation area will remain functional

Nanoknife causes irreversible damage to tumor cells and induces cell apoptosis. Cell apoptosis will stimulate the immune system to cell death. The human body will identify cell apoptosis as normal cell death and pure apoptotic tissue through cytophages, thereby promoting the regeneration and restoration of normal tissue.

5) Real-time monitoring during treatment

The nanoknife can be controlled and monitored using ultrasound, CT or MRI. There are only a few millimeters in size difference between ablation regions controlled by ultrasound or CT, which are measured by pathological analysis.

Images can also clearly show residual tumor tissue, which doctors can ablate again. Moreover, real-time monitoring allows doctors to monitor changes in surrounding tissues in the ablation area and predict the possibility of complications to ensure patient safety.

6) Application in difficult cases

Traditional ablation cannot be applied when the tumor is close to areas such as large vessels, bile ducts, pancreatic ducts, and portal vein in the liver.

Other ablation methods cause nerve damage, which leads to paralysis and loss of sexual ability if cancer happens to the prostate gland or close to the spine. A nano-knife does not cause such damage to vital organs. This is so far the best ablation method for patients who have experienced the problems mentioned above.


The cost of nanoknife therapy is $ 21,150.

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